EXPLAIN ALSO. Transcribed Image Text: Studies have shown that activity by a protein known as CREB-binding protein (CBP) results in increased amounts of gene transcription.

EXPLAIN ALSO. Transcribed Image Text: Studies have shown that activity by a protein
known as CREB-binding protein (CBP) results
in increased amounts of gene transcription.
Patients with a neurological condition known
as Rubinstein-Taybi Syndrome, which causes
mental retardation and skeletal abnormalities,
have been shown to have a mutation in the
gene that codes for this protein, resulting in
reduction in histone acetylation and reduced
gene transcription. Given this information,
which of the following could describe the
normal functioning of CBP?
A. CBP adds acetyl groups to the sugar-
phosphate backbone of the histone core
DNA, causing the DNA to open up and
become less condensed
B. CBP removes acetyl groups from the side
chains of amino acids in histone tails, causing
the chromatin to decondense and allowing
access to previously hidden promoter regions.
C. CBP adds acetyl groups to the side chains
of amino acids in histone tails, causing the
chromatin to decondense and allowing access
to previously hidden promoter regions.
D.CBP removes acetyl groups from the sugar-
phosphate backbone of the histone core
DNA, causing the DNA to open up and
become less condensed.

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